Articles listed by date

Results for 22 December 2020

Research Highlight | December 22, 2020

Seeking international standards for colon cancer surgery

A TRI-sponsored trial seeks to establish best practices for colorectal surgeons around the world

Results for 15 December 2020

Research Highlight | December 15, 2020

Electrical stimulation doesn’t seem to hasten stroke recovery 

Device may help wearers, but trial indicates it doesn’t aid long-term rehabilitation

Results for 13 November 2020

Research Highlight | November 13, 2020

Reassessing targets for managing kidney disease

Trial suggests doctors in Japan may be overtreating anemia in patients with non-diabetic kidney failure

Results for 18 September 2020

Research Highlight | September 18, 2020

Taking a whole-body approach to cancer screening

Whole-body screens that include positron-emission tomography can identify cancers that may otherwise go undetected

Results for 19 August 2020

Research Highlight | August 19, 2020

New life for old heart drug

Clinicians may have abandoned a lipid-lowering drug too soon, suggests a new study, which finds evidence for its disfavor lacking.

Results for 6 July 2020

Research Highlight | July 6, 2020

The ABCs of dementia

A scale could evaluate degrees of dementia, and plot the condition’s development more accurately.

Results for 21 April 2020

Feature | April 21, 2020

Working together to accelerate medical innovation

Chinese and Japanese participants gathered in Chengdu to discuss advanced medicine

Results for 30 January 2020

Research Highlight | January 30, 2020

Weakness in conventional allergy treatment revealed

Raised levels of an antibody thought to indicate tolerance to food allergens in people with established allergies suggests commonly accepted treatments are not universally effective for adults.

Results for 23 January 2020

Research Highlight | January 23, 2020

Neuroendovascular therapy on the rise in aging Japan

 A minimally invasive surgery for vascular conditions in the brain and spine is safe, even for the elderly, as long as patients are chosen with care

Results for 20 December 2019

The Principles Of Regenerative Medicine | December 20, 2019


Masanori Fukushima, TRI Director, Foundation for Biomedical Research and Innovation at Kobe, Translational Research Center for Medical Innovation (TRI)

The Principles Of Regenerative Medicine | December 20, 2019

An overview of regenerative medicine: its principles and the scope of the current revolution

Masanori Fukushima, TRI Director, Foundation for Biomedical Research and Innovation at Kobe, Translational Research Center for Medical Innovation (TRI)

The Principles Of Regenerative Medicine | December 20, 2019

Stem-cell therapy 2: Tissue regeneration by Muse cells after acute myocardial infarction

Shinya Minatoguchi*†, Yoshihisa Yamada‡,  Shingo Minatoguchi‡,  Toshiki Tanaka‡,  Atsushi Mikami*,  Shohei Wakao§,  Yoshihiro Kushida§  and  Mari Dezawa§ 

The Principles Of Regenerative Medicine | December 20, 2019

Stem-cell therapy 3: Cell-based neovascularization therapy for peripheral arterial disease 

Yasuyuki Fujita and Atsuhiko Kawamoto

The Principles Of Regenerative Medicine | December 20, 2019

Tissue engineering 1: Autologous transplantation of peripheral blood CD34+ cells in patients with femoral and tibial fracture non-union

Ryosuke Kuroda, Tomoyuki Matsumoto and Takahiro Niikura

The Principles Of Regenerative Medicine | December 20, 2019

Tissue engineering 2: Transplantation of cultivated autologous oral mucosal epithelial sheets in order to restore sight

Chie Sotozono*, Tsutomu Inatomi*†, Takahiro Nakamura*, Noriko Koizumi‡,  Kojiro Imai§, Shigeru Kinoshita*| , Yasuko Kimura¶ , Masahiro J. Go¶  and Masanori Fukushima¶   

The Principles Of Regenerative Medicine | December 20, 2019

Tissue engineering 3: A tissue-engineering approach to tympanic membrane regeneration

Shinichi Kanemaru

Feature | December 20, 2019

Medical technology advancing along key fronts

Disruptive strategies for treating diseases, new medical devices and big data are set to transform medical treatment

Research Highlight | December 20, 2019

New hope for stroke and spinal injury

Treatment based on stem cells aims to actively repair brain and spinal cord tissue damaged by stroke or spinal cord injury

Research Highlight | December 20, 2019

Cells could help heal a broken heart

A recently discovered cell type may help improve the long-term outlook after heart attack

Research Highlight | December 20, 2019

Reducing risk to life and limb through stem cell therapy

Stem cells offer hope for patients with critical limb ischemia, a potentially fatal circulatory disease of the legs

Research Highlight | December 20, 2019

Stem cells deployed to unite broken bones that refuse to heal

Stem cell therapy assists healing broken bones in combination with bone graft surgery

Research Highlight | December 20, 2019

Reducing cornea damage by transplanting cells from mouth

Transplanting sheets of cells grown in the lab onto the eye improves vision in patients suffering from severe disorders of the surface of their eyes

Research Highlight | December 20, 2019

Stimulating stem cells to heal burst eardrums

A sponge in the ear could become a safer and more convenient treatment for burst eardrums

Results for 30 October 2019

Infographic | October 30, 2019

Prostate cancer

People with cancer of the prostate currently have numerous treatment options available to them. But one of the most established, a type of radiation therapy known as brachytherapy, seems to be falling out of favour with clinicians.

Results for 23 August 2019

Research Highlight | August 23, 2019

A budding prognostic tool

Analysis of the invasive front of colorectal tumours provides a useful prognostic factor to aid in treatment decisions

Results for 8 August 2019

Feature | August 8, 2019

Spinal cord treatment using stem cells

After a small-scale clinical trial, a promising stem-cell treatment for spinal cord injuries is now available in Japan

Results for 18 July 2019

Research Highlight | July 18, 2019

A checklist to predict need for care

Cognition questions on a widely used frailty assessment can help identify those who will soon require long-term care

Research Highlight | July 18, 2019

The value of a second opinion

A three-year nationwide study suggests that specialized pathologists should be consulted to confirm gastrointestinal stromal tumour diagnosis

Results for 11 March 2019

Research Highlight | March 11, 2019

Precise sorting of tumours may improve treatment

Close evaluation of colon cancer progression, and disease characteristics, could hone treatment options

Results for 21 December 2018

Feature | December 21, 2018

Producing fit and active centenarians

TRI is striving to enliven society by harnessing the power of regenerative medicine

Research Highlight | December 21, 2018

Preventing spinal cord injuries is a numbers game

A longitudinal investigation at the Hyogo Rehabilitation Center suggests that age-targeted preventative strategies could reduce the incidence of spinal cord injuries

Results for 20 December 2018

Infographic | December 20, 2018

Liver cirrhosis

Once thought to be irreversible, cirrhosis of the liver now seems treatable — and drug development is proceeding apace.

Results for 30 November 2018

Research Highlight | November 30, 2018

A stem cell fix for limbs

Patients with renal failure and blocked arteries in their legs respond favorably to a new kind of stem cell therapy

Research Highlight | November 30, 2018

Narrowing a treatment plan for asthma

Asthma attacks come in three forms, and each requires a different management approach

Results for 8 November 2018

Infographic | November 8, 2018

Ulcerative colitis

Ulcerative colitis is a debilitating and incurable condition. But researchers have found fresh angles of attack, and a host of upcoming treatments raise the prospect of a durable victory against this common form of inflammatory bowel disease.

Results for 12 October 2018

Research Highlight | October 12, 2018

Weighing the Asian response to statins and stroke risk

Understanding the long-term use of statins for preventing stroke recurrence in Asian patients

Research Highlight | October 12, 2018

Tight quality control pays off for prostate cancer treatment

Standardized nationwide staff training in prostate cancer treatment in Japan contributes to high patient survival rates 

Results for 14 September 2018

Research Highlight | September 14, 2018

Validating biomarkers for Alzheimer’s disease across ethnicities

Are the markers of early Alzheimer’s disease similar across populations?

Research Highlight | September 14, 2018

Milk thistle extract could prevent cognitive decline in Alzheimer’s disease patients

Blocking amyloid assembly in blood vessels is a promising strategy for slowing dementia

Results for 23 August 2018

Feature | August 23, 2018

Collaborating against cancer

Convening for the fourth year, Japanese and Taiwanese academics continue to push forward together to tackle critical medical science issues.

Results for 25 July 2018

Research Highlight | July 25, 2018

Quick questionnaire for Alzheimer’s disease

A new questionnaire to help detect and monitor Alzheimer’s disease

Results for 13 June 2018

Feature | June 13, 2018

Casting a wider net for big data benefits

Embracing big data promises to expand the knowledge brought by clinical trials and lead to safer therapies

Research Highlight | June 13, 2018

Growth factor restores scarred vocal cords

A first-in-human clinical trial demonstrates the safety and efficacy of growth factor-based therapy for vocal fold scarring

Results for 2 May 2018

Research Highlight | May 2, 2018

Surgery brings on the smooth talk

A Japanese surgical procedure gives patients their voices back

Results for 19 April 2018

Feature | April 19, 2018

Launching a wealth of medical knowledge

An authoritative source of medical information for almost 120 years, the MSD manuals are now freely available online in Japanese

Results for 7 March 2018

Feature | March 7, 2018

Living well to a hundred and beyond

The public were given a preview of therapies that promise to preserve the quality of life of people well into old age

Feature | March 7, 2018

The harmony of standardized data

Translational and clinical research is hampered by the ‘dissonant notes’ of poor efficacy systems and a lack of data standards, claim researchers and policymakers. Fixing these problems can save lives.

Results for 14 December 2017

Infographic | December 14, 2017

Repairing the neural highway

The spinal cord rarely repairs itself when damaged, but ways of encouraging nerves to regrow are on the horizon.

Results for 30 November 2017

Research Highlight | November 30, 2017

Preventing stroke in Asian populations

A common cholesterol drug could help prevent certain types of strokes in Asian people

Results for 29 November 2017

Research Highlight | November 29, 2017

Repurposed drug could help clear toxic plaques in Alzheimer’s disease

Boosting the flow of blood to the brain could slow cognitive decline in patients.

Results for 26 October 2017

Feature | October 26, 2017

Stem cell therapies demonstrating their potential

CD34 positive stem cells could be used to treat a wide range of medical conditions

Research Highlight | October 26, 2017

A better view for healing hearts

An infrared imaging technique effectively facilitates stent insertion into blocked heart vessels

Infographic | October 26, 2017

Closing the gap

A bone fracture that fails to heal after initial treatment can lead to prolonged disability. Regenerative therapies might help to restart the bone-healing process, getting the people affected back in action.

Results for 23 August 2017

Infographic | August 23, 2017

Saving life and limb

Many people with critical limb ischaemia have no option but to have the affected limb amputated. Can regenerative medicine offer an alternative?

Results for 5 July 2017

Research Highlight | July 5, 2017

Saving limbs by growing new blood vessels

Stem cell therapy offers hope of rescuing blood-starved limbs

Results for 4 July 2017

Research Highlight | July 4, 2017

A stem cell fix for spinal injury

Stem cells derived from bone marrow could help people with damaged spinal cords to recover

Research Highlight | July 4, 2017

Stem cell therapy could help fractures heal better faster

A stem cell treatment offers a faster and less invasive way to fix fractured bones that have failed to heal

Research Highlight | July 4, 2017

Regenerative fix is music to the ears

A growth factor helps repair ruptured eardrums without invasive surgery

Feature | July 4, 2017

Clinical trials on trial

Poor standards in clinical trials waste time and money, and cost lives. Global cooperation is the only way to raise the bar.

Feature | July 4, 2017

From lab to clinic

TRI director Masanori Fukushima says considering disease mechanisms are the key to providing medicines to ease the journey into old age

Research Highlight | July 4, 2017

A bit of cheek restores sight

Cells transplanted from inside the mouth could restore sight in people blinded by disease, but practical challenges may hamper therapy delivery

Results for 21 June 2017

Infographic | June 21, 2017

Marching to a new beat

In the most severe cases, a ruptured eardrum can require surgery to put it right, but tissue-engineering techniques might provide a much simpler solution.

Results for 19 April 2017

Infographic | April 19, 2017

Let there be sight

Loss of the stem cells that constantly renew the surface of the cornea causes pain and, in some cases, blindness. Advances in transplantation and cell culture are helping to restore vision to even the most severely affected people.